Sr. Principal Scientist, Neurodegeneration

Senior Principal Scientist, Neurodegeneration This role is based on site at our Upper Providence, PA location. Job Purpose We are seeking a highly motivated and talented scientific laboratory leader with a strong background in neuroscience to join our growing Respiratory Immunology Inflammatory Research Unit (RIIRU) at GSK's Upper Providence research facility in the United States. The mission for RIIRU is to target diseases by harnessing the power of the immune system.

The ideal candidate will work within a dynamic team to support research in neurodegenerative diseases (ND) such as AD, PD, and ALS. Key Responsibilities Lead biology studies both from/off-bench to support discovery projects by developing target - disease biology hypothesis, establishing and performing iPSC derived CNS cells/ex vivo cellular assays primarily using biochemistry expertise combined with molecular and cell biology. Develop novel assays with high translational value to interrogate target or disease biology.

Develop testable target and biomarker hypothesis based on Omics data. Optimize and perform in vitro assays to support lead optimization of molecules. Work collaboratively with matrix partners to lead workstreams towards project milestone.

Periodically update work status to project teams, matrix partners, and senior stakeholders. Manage time efficiently and be productive when there are competing priorities. Be compliant with GSK policies and SOPs including recording electronic laboratory notebooks, maintaining safety while working in the lab.

Basic Qualifications PhD in Biochemistry, preferably in Alzheimer's disease with 5+ years drug discovery experience in industry. Three or more years of experience in leading biology studies in early-stage drug discovery projects. Three or more years of experience in protein isolation from iPS derived cells, human brain/biofluid samples, and characterization using biochemical and mass spectrometric methods. 8+ years' experience working with iPSC derived CNS cells and standard laboratory techniques such as cell biology, molecular biology and biochemistry. 5+ years' experience in developing assays to investigate target mechanisms/bio-logic preferably in Alzheimer's disease using iPSC derived cells in 2D configuration. 3+ years' experience in using AI/ML tools to develop biological/mechanistic hypothesis using omic datasets.

Preferred Qualifications Proficiency in conceptualizing, designing and developing complex assays utilizing different cellular models including primary and hiPSC-derived cells (neuron/microglia/astrocytes). 5+ years deep multidisciplinary expertise in biological mass spectrometry, quantitative proteomics including isotope labeling (SILAC) and label-free techniques and targeted proteomics workflow. 5+ year's experience in deploying cell-based target engagement assays and establishing proximal functional pharmacology. Demonstrated ability to work effortlessly in a collaborative and multidisciplinary team environment. Effective communication skills and being proactive at work.

If you require an accommodation or other assistance to apply for a job at GSK, please contact the appropriate Recruitment Staff by emailing us at [email protected]. GSK is an Equal Opportunity Employer. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, religion, sex (including pregnancy, gender identity, and sexual orientation), parental status, national origin, age, disability, genetic information (including family medical history), military service or any basis prohibited under federal, state or local law.

GSK does not accept referrals from employment businesses and/or employment agencies in respect of the vacancies posted on this site. All employment businesses/agencies are required to contact GSK's commercial and general procurement/human resources department to obtain prior written authorization before referring any candidates to GSK. Please note that if you are a US Licensed Healthcare Professional or Healthcare Professional as defined by the laws of the state issuing your license, GSK may be required to capture and report expenses GSK incurs, on your behalf, in the event you are afforded an interview for employment.

For more information, please visit the Centers for Medicare and Medicaid Services (CMS) website at https://openpaymentsdata.cms.gov/. #J-18808-Ljbffr